1. Scope

1.1 This test method provides procedures for validating enthalpic measurements of differential scanning calorimeters (DSC) and analytical methods based upon the measurement of enthalpy or heat by DSC. Performance parameters determined include calorimetric repeatability (precision), detection limit, quantitation limit, linearity and bias. This test method is applicable to both exothermic and endothermic events.

1.2 Validation of apparatus performance and analytical methods is requested or required for quality initiatives or where results may be used for legal purposes.

1.3 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.

ASTM Standards

E177 Practice for Use of the Terms Precision and Bias in ASTM Test Methods

E473 Terminology Relating to Thermal Analysis and Rheology

E967 Test Method for Temperature Calibration of Differential Scanning Calorimeters and Differential Thermal Analyzers

E968 Practice for Heat Flow Calibration of Differential Scanning Calorimeters

E1142 Terminology Relating to Thermophysical Properties

E1860 Test Method for Elapsed Time Calibration of Thermal Analyzers

E1970 Practice for Statistical Treatment of Thermoanalytical Data

E2161 Terminology Relating to Performance Validation in Thermal Analysis

Keywords

detection limit; differential scanning calorimetry; enthalpy; linearity; precision; quantitation limit; range; repeatability; thermal analysis; validation; Calorimeter; Detection method; Differential scanning calorimetry (DSC); Endothermic temperature analysis; Enthalpy; Exothermic temperature analysis; Heat flow; Linear changes/linearity; Quantitation estimate; Repeatability/reproducibility (RR); Thermal analysis (TA); Validation

ICS Code

ICS Number Code 17.200.10 (Heat. Calorimetry)

DOI: 10.1520/E2253-08

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