ASTM E2045-99(2003)
Historical Standard: ASTM E2045-99(2003) Standard Practice for Detailed Clinical Observations of Test Animals
SUPERSEDED (see Active link, below)
ASTM E2045
1. Scope
1.1 This practice describes the terms used in observing and recording cutaneous, gastrointestinal, respiratory, reproductive, neuromuscular, ocular, and general clinical signs of animals undergoing toxicological testing. This practice also assists in properly observing and assessing laboratory animals for signs of disease or adverse effects of compound administration.
1.2 This practice includes codes and descriptions for a wide variety of clinical signs, anatomical locations, and other descriptive qualifiers, and a technique for scoring the extent or severity of clinical signs.
1.3 This practice assumes that the reader is knowledgeable in animal toxicology and related pertinent areas and is trained in making clinical observations.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
Federal Standards
Title40, Code of Federal Regulations (CFR), Environmental Protection Agency, Part 798, Health Effects Testing GuidelinesKeywords
adverse reactions; animals; clinical codes; clinical signs; toxicity; Adverse reactions; Animal habitats; Clinical codes/signs; Cutaneous signs; Gastrointestinal analysis; General clinical codes/signs; Laboratory animals; Neuromuscular signs; Ocular signs; Reproductive signs; Respiratory signs; Toxicity/toxicology;
ICS Code
ICS Number Code 11.220 (Veterinary medicine)
DOI: 10.1520/E2045-99R03
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