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  • ASTM
    E1262-24 Standard Guide for Performance of Chinese Hamster Ovary Cell/Hypoxanthine Guanine Phosphoribosyl Transferase Gene Mutation Assay
    Edition: 2024
    $86.11
    Unlimited Users per year

Description of ASTM-E1262 2024

ASTM E1262-24

Active Standard: Standard Guide for Performance of Chinese Hamster Ovary Cell/Hypoxanthine Guanine Phosphoribosyl Transferase Gene Mutation Assay




ASTM E1262

Scope

1.1 This guide highlights some of the more relevant biological concepts as they are currently understood, and summarizes the critical technical aspects for acceptable bioassay performances as they currently are perceived and practiced. The Chinese hamster ovary cell/hypoxanthine guanine phosphoribosyl transferase (CHO/HGPRT) assay (1)2 has been widely applied to the toxicological evaluation of industrial and environmental chemicals. The method is limited to detection of small-scale genetic interactions. Therefore, when this method is used for genotoxicity assessment it is recommended that an in vitro clastogenicity assay (for example, chromosomal aberration, micronucleus) is considered to detect large-scale (for example, chromosomal) DNA damage.

1.2 This guide concentrates on the practical aspects of cell culture, mutagenesis procedures, data analysis, quality control, and testing strategy. The suggested approach represents a consensus of the panel members for the performance of the assay. It is to be understood, however, that these are merely general guidelines and are not to be followed without the use of sound scientific judgement. Users of the assay should evaluate their approach based on the properties of the substances to be tested and the questions to be answered.

1.3 Deviation from the guidelines based on sound scientific judgement should by no means invalidate the results obtained.

1.4 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.

1.6 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.


Keywords


ICS Code

ICS Number Code 07.080 (Biology. Botany. Zoology)


DOI: 10.1520/E1262-24

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