Cart (0)
- No items in cart.
Total
$0
There is a technical issue about last added item. You can click "Report to us" button to let us know and we resolve the issue and return back to you or you can continue without last item via click to continue button.
Not a subscriber? Register for a trial account.
Already a subscriber? 
MADCAD.com Free Trial
Sign up for a 3 day free trial to explore the MADCAD.com interface, PLUS access the
2009 International Building Code to see how it all works.
If you like to setup a quick demo, let us know at support@madcad.com
or +1 800.798.9296 and we will be happy to schedule a webinar for you.
| Email * | |
| Password * | |
| Confirm * | |
| First Name * | |
| Last Name * | |
| Title | |
| Company Name * | |
| Company Size * | |
| Industry * | |
| Address * | |
| Address 2 | |
| City * | |
| State * |
Zip *
|
| Country * | |
| Phone * | |
| How did you hear about MADCAD.com? * |
|
Reset password
Enter your personal account email address to request
a password reset:
a password reset:
Reset password
Enter your account email address to request
a password reset:
a password reset:
Security check
Please login to your authorized staff account to use this feature.
Are you sure you want to empty the cart?
Report To Us
Contact us for a custom quote
⨯To continue with accurate pricing,
please select your company type below:
⨯We need your input!
Are you a code official in a jurisdiction with less than 300,000 population?
⨯ We need your input!
Download File
Expand All
TOC Search:
UNC Chapel Hill - Department of Facilities Services - Laboratory Design Guidelines, 2013
- UNC LABORATORY DESIGN GUIDELINES
- TABLE OF CONTENTS
- I. INTRODUCTION [Go to Page]
- Must: Criterion is based on well-established consensus standards//guidelines. “Must” is used to reflect a UNC requirement, although not required by a regulation. The user of the Guide is required to include the design feature.
- Should: Criterion is advisory in nature, based on good engineering and safety practices. It is the discretion of the user of the Guide to include the design feature.
- Limitations of the Guide:
- The EHS Laboratory Design Guide is not "all inclusive." It does not cover all regulatory issues nor does it cover all design situations. It is important to note that use practices must be considered during the design process, as they can directly infl...
- II. GENERAL REQUIREMENTS FOR UNC-CHAPEL HILL LABORATORIES [Go to Page]
- 1.
- 1. Codes, Standards, and References [Go to Page]
- i. Regulations:
- 1. Federal Code of Regulations (“CFR”), Title 29, Labor
- 2. NC Building Code
- 3. NC Fire Prevention Code
- 4. NC Mechanical Code
- 5. CDC Select Agents, Title 42, Part 73
- 6. National Fire Protection Association (“NFPA”) Handbook 70
- 7. National Electric Code
- 8. NC Radiation Control Regulations
- ii. Consensus Standards and References
- 1. American National Standard for Laboratory Ventilation (ANSI/AIHA Z9.5-)
- 2. American National Standard for Thermal Environmental Conditions for Human Occupancy (ANSI/ASHRAE 55-1992)
- 3. NC Radiation Protection Section
- 4. "Safe Handling of Radioactive Materials", National Council on Radiation Protection (NBS 92) Handbook
- 5. "Safe Handling of Radionuclides", International Atomic Energy Agency, Safety Series No. 1, (1973 ed. is still current as of 1999) (IAEA)
- 6. CDC-NIH Biosafety in Microbiological and Biomedical Laboratories, 5th (or latest) Edition
- 7. Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines), April 2002 (or latest)
- 8. Reducing the Risks of Nonstructural Earthquake Damage: A Practical Guide, Federal Emergency Management Agency: FEMA-74, 1994
- 2. Scope
- 3. Architectural Considerations [Go to Page]
- i.
- i. Walls/Doors/Security
- ii.
- iii. Windows
- iv. Flooring
- v. Sinks
- vi. Chemical/Waste Storage
- vii. Furniture Design and Location/Exit Paths
- viii. Cleanability
- ix. Breakrooms
- x. General Ventilation Considerations (see also Section 2.2 for fume hood considerations)
- xi. Casework and counter top recommendations
- 1. Casework:
- xii. Engineering Considerations
- a.
- a.
- a. Electrical
- b. Plumbing
- III. FUME HOODS [Go to Page]
- 1. Fume Hood Location
- 2. Approved Equipment
- 3. Selection/Types [Go to Page]
- i.
- i. General: Consider the following factors when selecting fume hood:
- 1. Room size (length x width x height)
- 2. Number of room air changes
- 3. Lab heat load
- 4. Types of materials used
- 5. Linear feet of hood needed based on
- 6. Number of users/hood
- 7. Frequency of use
- 8. % of time working at hood
- 9. Size of apparatus to be used in hood, etc.
- ii. Constant Volume Hoods
- iii. Variable Air Volume (VAV) fume hoods
- iv. Supply or auxiliary air hoods: These hoods are not permitted for new construction.
- v. Ductless Fume Hoods:
- vi. Perchloric Acid Hoods:
- vii. Radioactive Material Use
- 1.
- 1. Fume hoods intended for use with radioactive isotopes must be constructed of stainless steel or other materials that will not be corroded by the chemicals used in the hood.
- 2. The interior of all radioisotope hoods must have coved corners to facilitate decontamination.
- 3. The hood exhaust may require filtration by HEPA or Charcoal/HEPA filters. Where such is the likelihood, the hood must have a bag-out plenum for mounting such filters and fan capacity for proper operation of the hood with the filter installed. The m...
- 1.
- 4. The cabinet on which the hood is installed shall be adequate to support shielding for the radioactive materials to be used therein.
- 5. In general, glove boxes with HEPA filtered exhausts shall be provided for operations involving unsealed radioactive material that emit alpha particles. Consult with the Radiation Safety Section of EHS for specific requirements.
- viii. American with Disabilities Act (ADA) Hoods:
- ix. Glove Boxes:
- x. Floor mounted (walk-in) Fume Hoods:
- xi. Special Purpose Hoods:
- 4. Labeling
- 1.
- 1.
- 1.
- 1.
- 1.
- 5. Construction, Installation & Performance
- 6. Face Velocity
- 7. Certification [Go to Page]
- i. Two horizontal sashes open (vertical sash lowered)
- ii. Vertical sash at 18 inches
- iii. The sash fully open.
- 8. Power and Electrical
- 9. Sashes
- 10. Ducting [Go to Page]
- i. Perchloric acid hoods
- ii. Hoods with wash down equipment
- iii. Hoods that could deposit highly hazardous residues on the ductwork
- iv. Hoods requiring HEPA filtration or other special air cleaning
- v. Situations where the mixing of exhausted materials may result in a fire, explosion, or chemical reaction hazard in the duct system
- 11. Exhaust [Go to Page]
- Chemical CAS Reg # (Percent)
- i. 2-Acetylaminofluorene 53963 (1.0)
- ii. 4-Aminodiphenyl 92671 (0.1)
- iii. Benzedrine (and its salts) 92875 (0.1)
- iv. 3, 3’-Dichlorobenzidine 91941 1.0
- v. 4-Dimethylaminoazobenzene 60117 (1.0)
- vi. alpha-Naphthylamine 134327 (1.0)
- vii. beta-Naphthylamine 91598 (0.1)
- viii. 4-Nitrobiphenyl 92933 (0.1)
- ix. N-Nitrosodimethylamine 62759 (1.0)
- x. beta-Propiolactone 57578 (1.0)
- xi. bis-Chloromethyl ether 542881 (0.1)
- xii. Methyl chloromethyl ether 107302 (0.1)
- xiii. Ethyleneimine 151564 (1.0)
- xiv. 1, 2-Dibromo-3-Chloropropane
- xv. Asbestos
- xvi. Vinyl Chloride
- xvii. Acrylonitrile
- xviii. Inorganic Arsenic
- xix. Ethylene Dibromide
- xx. Ethylene Oxide
- xxi. Methylene Chloride
- 12. Noise
- 13. Testing
- IV. EMERGENCY EYEWASH AND SAFETY SHOWER EQUIPMENT [Go to Page]
- 1. Codes, Standards, and References [Go to Page]
- a)
- a) Regulations, Consensus Standards, and References [Go to Page]
- i. American National Standards Institute (ANSI), Z358.1-2004
- ii. A Guide to Eyewash and Safety Shower Facilities, NCOSHA
- iii. National Fire Protection Association
- iv. Health Care Facilities, Handbook 99, Chapter 10-6, Emergency Shower
- 2. Scope
- 3. General Location [Go to Page]
- i.
- i. Where to Install
- ii. Signage
- iii. Prohibitions around Equipment
- 4. Eyewash Requirements [Go to Page]
- i.
- i. Flushing Rates
- 5. Eyewash Positioning
- 6. Eyewash Activation
- 7. Eyewash Equipment Protection
- 8. Deluge Shower Requirements [Go to Page]
- 1. Deluge Shower Positioning
- 2. Flushing Rates
- 9. Equipment Activation
- 10. Design for Maintenance/Use
- 11. Testing
- 12. Approved Equipment
- V. COMPRESSED GAS CYLINDERS [Go to Page]
- 1. Codes, Standards, and References [Go to Page]
- i.
- i.
- i. NFPA 45, Chapter 8
- ii. NFPA 99, Chapter 4
- iii. NFPA 704, Chapter 2
- 2. Scope
- 3. Storage of Compressed Gas Cylinders – General Location [Go to Page]
- i. They are protected from external heat sources such as flame impingement, intense radiant heat, electric arc, or high temperature steam lines.
- ii. They are in a well protected, well ventilated, dry location, at least 20 feet from highly combustible materials.
- a) Restraint Systems
- 4. Storage of Compressed Gas Cylinders – Toxic and Highly Toxic Gases [Go to Page]
- a) Storage Systems [Go to Page]
- i. ventilated gas cabinets/exhausted enclosures/ laboratory fume hoods; or
- ii. separate ventilated gas storage rooms without other occupancy or use, which has explosion control.
- i. located in a room or area which has independent exhaust ventilation;
- ii. operate at negative pressure in relation to the surrounding area;
- iii. have self-closing limited access parts or noncombustible windows toprovide access to equipment controls, with an average face velocity of at least 200 fpm and with a minimum of 150 fpm at any part of the access port or window;
- iv. connected to an exhaust system;
- v. have self-closing doors and is constructed of at least 0.097 inch (12 gauge) steel;
- vi. internally sprinklered;
- vii. anchored;
- viii. contain not more than 3 cylinders per gas cabinet, except where cylinder contents are 1 pound net or less, in which case gas cabinets may contain up to 100 cylinders.
- i. Operate at a negative pressure in relation to the surrounding area;
- ii. Direct the exhaust ventilation to an exhaust system.
- b) Treatment
- c) Emergency Power
- d) Detection System
- e) Security
- 5. Storage of Compressed Gas Cylinders – Medical Gases [Go to Page]
- i. Operated at a negative pressure in relation to surrounding area,
- ii. Provided with self-closing, limited-access ports or noncombustible windows to give access to equipment controls. The average velocity of ventilation at the face of access ports or windows shall not be less than 200 feet per minute, with a minimum ...
- iii. Connected to an exhaust system,
- iv. Provided with a self-closing door,
- v. Constructed of not less than 0.097-inch (12 gage) steel, and
- vi. Internally sprinklered.
- VI. FLAMMABLE LIQUID STORAGE CABINETS [Go to Page]
- 1. Codes, Standards, and References [Go to Page]
- 1. NC Fire Prevention Code Section
- 2. NFPA 30 Chapter 4
- 2. Scope
- 3. Design [Go to Page]
- 1. Approval/Submittal
- 1.
- 1.
- 2. Cabinet Capability
- 3. Labeling
- 4. Construction [Go to Page]
- 1. Materials (NFPA 30, Section 4-3.3(b))
- 2. Doors
- 3. Venting (NFPA 30, Chapter 4-3.4 and NFPA 99, Chapter 10-7.2.3)
- 4. Location
- 5. Laboratory design must ensure that Flammable Liquid Storage Cabinets are NOT located near an open flame or other ignition source.
- 6. Good Practice per UNC-Chapel Hill EHS
- 7. An open flame or other ignition source could start a fire or cause an explosion if an accident or natural disaster brought the ignition source and flammable liquids or vapors together.
- VII. HAZARDOUS MATERIALS STORAGE AND HANDLING [Go to Page]
- 1. Standards
- 2. Scope
- 3. Requirements [Go to Page]
- 1. Highly toxic flammable or toxic flammable gases when not stored in gas cabinets, exhausted enclosures or gas rooms.
- 2. Combustible dusts.
- 3. Class 4 oxidizers.
- 4. Unclassified detonable and Class 1 organic peroxides.
- 5. Pyrophoric gases.
- 6. Class 3 and 4 unstable (reactive) materials.
- 7. Class 2 and 3 water-reactive solids and liquids.
- 4. Procedures [Go to Page]
- 1. NC Building Code Chemical Inventory Report Procedure
- 2. Hazardous Waste Generator "permit" for "off campus" facilities
- 3. City Water Quality Control
- 4. Decommissioning of Existing Facilities
- VIII. ADDITIONAL REQUIREMENTS FOR LABORATORIES USING RADIOACTIVE MATERIALS, RADIATION PRODUCING MACHINES, OR LASERS [Go to Page]
- 1. Codes, Standards, and References [Go to Page]
- 1. Regulations:
- 2. University Policies:
- 3. Recommendations:
- 2. Scope
- 3. Decommissioning of Existing Facilities Prior to Demolition or Renovation
- 4. Design Features for Radiological Labs [Go to Page]
- 1. Approval Process
- 1.
- 2. Architectural Considerations
- 3. Security
- 4. Waste Storage
- 5. Ventilation Considerations [Go to Page]
- Ventilation requirements for the laboratories utilizing radioactive materials are dependent upon the types of materials used. Facilities that use radioactive gases shall be equipped with ventilation to adequately maintain concentrations to below allow...
- 5. Laser Radiation Items
- 5. Laser Ventilation Considerations
- IX. BIOSAFETY LEVEL 2 LABORATORIES [Go to Page]
- 1. Codes, Standards, and References
- 2. Scope
- 3. Ventilation Considerations for Biosafety Level 2 Laboratories
- 4. Biological Safety Cabinets and Other Containment Considerations [Go to Page]
- 1. Approval/Type
- 2. Location
- 3. Natural Gas
- 4. Restraints
- 1.
- 1.
- 5. Testing
- 6. Autoclaves
- I.
- I.
- I.
- I.
- I.
- X. GLOSSARY [Go to Page]
- Biosafety Level:
- Biosafety levels consist of laboratory practices and techniques, safety equipment, and a laboratory facility appropriate for the operations performed and the hazard posed by the particular biohazard material. The Centers for Disease Control (CDC) and ...
- Biosafety Cabinet:
- A ventilated cabinet which serves as a primary containment device for operations involving biohazard materials. The three classes of biosafety cabinets are described below:
- Class I Biosafety Cabinet:
- The Class I biosafety cabinet is an openfronted negatively pressured ventilated cabinet with a minimum inward average face velocity at the work opening of at least 75 feet per minute. The exhaust air from the cabinet is filtered by a HEPA filter and d...
- Class II Biosafety Cabinet:
- The Class II biosafety cabinet is an open-fronted, ventilated cabinet. Exhaust air is filtered with a high efficiency particulate air filter (HEPA). This cabinet provides HEPA-filtered downward airflow within the workspace. Class II Cabinets are furth...
- Class III Biosafety Cabinet:
- The Class III biosafety cabinet is a totally enclosed, negative pressure, ventilated cabinet of gas-tight construction. Operations within the Class III cabinet are conducted through protective gloves. Supply air is drawn into the cabinet through high-...
- Boiling Point:
- The temperature at which the vapor pressure of a liquid equals the surrounding atmospheric pressure. For purposes of defining the boiling point, atmospheric pressure shall be considered to be 14.7 PSIA (760 mm Hg).
- Carcinogen:
- A substance is considered to be a carcinogen if:
- Combustible Liquid:
- A combustible liquid shall be defined as any liquid that has a closed-cup flash point at or above 100 F (37.8 C).
- Compressed Gas:
- Control Area:
- A building or portion of a building within which the exempted amounts of hazardous materials are allowed to be stored, dispensed, used or handled.
- Corrosive:
- A substance that causes visible destruction of, or irreversible alterations in, living tissue by chemical action at the site of contact. For example, a substance is considered to be corrosive if, when tested on the intact skin of albino rabbits by the...
- Decontamination:
- Removal or destruction of infectious agents; removal or neutralization of toxic agents.
- Emergency shower:
- A unit that enables a user to have flushing fluid cascading over the entire body.
- Explosive:
- A substance that causes a sudden, almost instantaneous release of pressure, gas, and heat when subjected to sudden shock, pressure, or high temperature.
- Eyewash:
- A device used to irrigate and flush the eyes.
- Flammable Anesthetic Gas:
- A compressed gas which is flammable and administered as an anesthetic including cyclopropane, divinyl ether, ethyl chloride, ethyl ether and ethylene.
- Flammable Liquid:
- Any liquid that has a closed-cup flash point below 100 F (37.8 C).
- Class I Liquid:
- Any liquid that has a closed-cup flash point below 100 F (37.8 C) and a Reid vapor pressure not exceeding 40 PSIA at 100 F (37.8 C).
- Flash Point:
- The minimum temperature of a liquid at which sufficient vapor is given off to form an ignitable mixture with air, near the surface of the liquid or within the vessel used.
- Fume Hood:
- A device enclosed on three sides, as well as the top and bottom, with an adjustable sash or fixed partial enclosure on the remaining side. They are designed, constructed and maintained so as to draw air inward by means of mechanical ventilation, and s...
- Hazardous Material:
- A material for which there is statistically significant evidence based on at least one study conducted in accordance with established scientific principles that acute or chronic health effects may occur in exposed employees. The term “health hazard” i...
- Hazard Warning:
- Any words, pictures, symbols, or combination thereof appearing on a label or other appropriate form of warning that convey the health and physical hazards of the substance(s) present.
- Highly Toxic:
- A substance is considered to be highly toxic if:
- HIV/HBV Research/Production Facility:
- A laboratory producing or using research laboratory scale amounts of HIV or HBV. Research laboratories may produce high concentrations of HIV or HBV but not in the volume found in production facilities.
- Irritant:
- A substance, which is not corrosive, but which causes a reversible inflammatory effect on living tissue by chemical action at the site of contact. A substance is a skin irritant if, when tested on the intact skin of albino rabbits by the methods of 16...
- NIH:
- National Institute of Health
- Nonflammable Medical Gas:
- A compressed gas, such as oxygen or nitrous oxide, which is nonflammable and used for therapeutic purposes.
- Organic Peroxide:
- An organic compound that contains the bivalent -O-O- structure and which may be considered to be a structural derivative of hydrogen peroxide where one or both of the hydrogen atoms has been replaced by an organic radical.
- Oxidizer:
- A substance, other than a blasting agent or explosive, that initiates or promotes combustion in other materials, thereby causing fire either of itself or through the release of oxygen or other gases.
- Pyrophoric:
- A substance that will ignite spontaneously in air at a temperature of 1300 F (54.40 C) or below.
- Risk Levels:
- Sensitizer:
- A substance that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the substance.
- Toxic:
- A substance is considered to be toxic if:
- Unstable (reactive):
- A substance which in the pure state, or as produced or transported, will vigorously polymerize, decompose, condense, or will become self-reactive under conditions or shocks, pressure or temperature.
- Vapor Pressure:
- The pressure, measured in PSIA, exerted by a liquid.
- Water-reactive:
- A substance that reacts with water to release a gas that is either flammable or presents a health hazard.
- (END OF SECTION) [Go to Page]
Copyright 2024 Compu-tecture, Inc.
All Rights Reserved.
About Us /
Careers /
support@madcad.com /
1.800.798.9296